Robust Estimation for Secondary Trait Association in Case-Control Genetic Studies
نویسندگان
چکیده
منابع مشابه
Practice of Epidemiology Robust Estimation for Secondary Trait Association in Case-Control Genetic Studies
Secondary trait genetic association provides insight into the genetic architecture of disease etiology but requires caution in estimation. Ignoring case-control sampling may introduce bias into secondary trait association. In this paper, we compare the efficiency and robustness of various inverse probability weighted (IPW) estimators andmaximum likelihood (ML) estimators. ML methods have been p...
متن کاملRobust estimation for secondary trait association in case-control genetic studies.
Secondary trait genetic association provides insight into the genetic architecture of disease etiology but requires caution in estimation. Ignoring case-control sampling may introduce bias into secondary trait association. In this paper, we compare the efficiency and robustness of various inverse probability weighted (IPW) estimators and maximum likelihood (ML) estimators. ML methods have been ...
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May 10, 2010 Type Package Title Robust tests for case-control genetic association studies Version 1.03 Date 2010-05-10 Author Yong ZANG , Wingkam FUNG , Gang ZHENG Maintainer Yong ZANG Depends R (>= 2.6.0), mvtnorm Description This package supplies several robust tests for case-control genetic association studies. The te...
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Case-control association studies use genetic markers as putative etiologic risk factors. The approach is controversial and has tended to produce associations in neuropsychiatry that do not stand the test of time. We studied the processes that can bias the outcomes away from a true representation of the relationship between a genetic marker and a neuropsychiatric disorder. If conducted with care...
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Motivated by the challenges associated with accounting for the ascertainment when analyzing secondary phenotypes that are correlated with case-control status, Lin and Zeng have proposed a method that properly reflects the case-control sampling (Lin and Zeng, 2009). The Lin and Zeng method has the advantage of accurately estimating effect sizes for secondary phenotypes that are normally distribu...
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ژورنال
عنوان ژورنال: American Journal of Epidemiology
سال: 2014
ISSN: 0002-9262,1476-6256
DOI: 10.1093/aje/kwu039